Nickel-Catalyzed Carbonylation Reaction of Aryl <i>N</i>-Tosylaziridines with Arylboronic Acids toward β-Amino Ketones
Pengfei Ji, Chen-Yang Hou, Boyu Yao, Tong Li, Xinxin Qi, Xiao‐Feng Wu
Abstract
High Resolution Image Download MS PowerPoint Slide A novel nickel-catalyzed carbonylation reaction of aryl N -tosylaziridines with arylboronic acids has been explored for the synthesis of β-amino ketones. By using formic acid as the CO source, a variety of β-amino ketones were obtained in moderate to excellent yields. This approach features high regioselectivity, good functional group tolerance, and a CO gas-free operation. It provides a good supplement for the ring-opening transformation of aziridines through a nickel-catalyzed radical carbonylation process.
Topics & Concepts
CarbonylationChemistryFormic acidArylCatalysisOrganic chemistryFunctional groupReaction conditionsMedicinal chemistryCombinatorial chemistryMethanolReaction mechanismTransformation (genetics)Yield (engineering)PalladiumSynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques