A System Based on Novel Parainfluenza Virus PIV5-L for Efficient Gene Delivery of B-Lymphoma Cells
Xiaoqing Liu, Lilan Zheng, Ting Wang, Ying Li, Bingbing Wu, Shujuan Du, Qing Zhu, Caixia Zhu, Yuyan Wang, Rong Zhang, Fang Wei, Qiliang Cai
Abstract
B-cell lymphoma is a common aggressive neoplastic disorder of lymphocytes. Delivery of genes of interest into B cells, particularly virus-mediated B-lymphoma cells, is still a challenge. In this study, we report that a system (L-VLP) based on the parainfluenza virus PIV5-L strain isolated from B cells had highly expressed exogenous genes and remained stable without obvious cell toxicity, which provides a potential new strategy for gene delivery and treatment of B-cell cancer.
Topics & Concepts
BiologyLymphomaVirologyGene deliveryVirusGenetic enhancementB-cell lymphomaCancer researchViral vectorVector (molecular biology)Kaposi's sarcoma-associated herpesvirusGeneImmunologyHerpesviridaeGeneticsRecombinant DNAViral diseaseVirus-based gene therapy researchParvovirus B19 Infection StudiesRespiratory viral infections research