Effective degradation of EGFRL858R+T790M mutant proteins by CRBN-based PROTACs through both proteosome and autophagy/lysosome degradation systems
Xiaojuan Qu, Haixia Liu, Xiaoling Song, Ning Sun, Hui Zhong, Xing Qiu, Xiaobao Yang, Biao Jiang
Topics & Concepts
T790MEpidermal growth factor receptorChemistryCancer researchCereblonProtein degradationLung cancerA549 cellCancer cellCancerGefitinibUbiquitinCellUbiquitin ligaseBiologyMedicineBiochemistryReceptorInternal medicineGeneProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisMultiple Myeloma Research and Treatments