Genomics of Trypanosomatidae: Where We Stand and What Needs to Be Done?
Vyacheslav Yurchenko, Anzhelika Butenko, Alexei Yu. Kostygov
Abstract
Trypanosomatids are easy to cultivate and they are (in many cases) amenable to genetic manipulation. Genome sequencing has become a standard tool routinely used in the study of these flagellates. In this review, we summarize the current state of the field and our vision of what needs to be done in order to achieve a more comprehensive picture of trypanosomatid evolution. This will also help to illuminate the lineage-specific proteins and pathways, which can be used as potential targets in treating diseases caused by these parasites.
Topics & Concepts
BiologyLineage (genetic)GenomicsEvolutionary biologyGenomeComputational biologyData scienceComputer scienceGeneticsGeneTrypanosoma species research and implicationsResearch on Leishmaniasis StudiesInsect symbiosis and bacterial influences