Single-cell transcriptomic landscape reveals tumor specific innate lymphoid cells associated with colorectal cancer progression
Jingjing Qi, Adeline Crinier, Bertrand Escalière, Youqiong Ye, Zhengting Wang, Tianyu Zhang, Luciana Batista, Hongzhi Liu, Liwen Hong, Ningbo Wu, Mingnan Zhang, Lei Chen, Yingbin Liu, Lei Shen, Émilie Narni-Mancinelli, Éric Vivier, Bing Su
Abstract
ILCs were observed in the blood of CRC patients. The SLAMF1-high group of CRC patients had a significantly higher survival rate than the SLAMF1-low group, suggesting that SLAMF1 is an anti-tumor biomarker in CRC.
Topics & Concepts
Innate lymphoid cellColorectal cancerCancer researchImmunologyBiologyImmunityCancerTumor microenvironmentInnate immune systemImmune systemMedicineInternal medicineIL-33, ST2, and ILC PathwaysImmune Cell Function and InteractionEosinophilic Esophagitis