A step-economic and one-pot access to chiral C<sup>α</sup>-tetrasubstituted α-amino acid derivatives <i>via</i> a bicyclic imidazole-catalyzed direct enantioselective <i>C</i>-acylation
Mo Wang, Muxing Zhou, Lu Zhang, Zhenfeng Zhang, Wanbin Zhang
Abstract
-tetrasubstituted α-amino acid derivatives with excellent enantioselectivities (up to 99% ee). This step-economic, one-pot, and auto-tandem strategy provides facile access to important chiral building blocks, such as peptides, serines, and oxazolines, which are often used in medicinal and synthetic chemistry.
Topics & Concepts
Enantioselective synthesisImidazoleBicyclic moleculeCatalysisChemistryAcylationStereochemistryCombinatorial chemistryOrganic chemistryAsymmetric Synthesis and CatalysisChemical Synthesis and AnalysisSynthesis and Catalytic Reactions