TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS
Xinxin Zuo, Jie Zhou, Yin‐Ming Li, Kai Wu, Zonggui Chen, Zhiwei Luo, Xiaorong Zhang, Yi Liang, Miguel A. Esteban, Yu Zhou, Xiang‐Dong Fu
Topics & Concepts
ProteostasisSOD1Amyotrophic lateral sclerosisOxidative stressBiologyProtein aggregationMitochondrionStress granuleCell biologyMitochondrial DNAGeneNeurodegenerationMutantGeneticsSuperoxide dismutaseBiochemistryDiseaseTranslation (biology)MedicineMessenger RNAPathologyAmyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders ResearchRNA Research and Splicing