The Pleiotropic Face of CREB Family Transcription Factors
Md. Arifur Rahman Chowdhury, Jungeun An, Sangyun Jeong
Abstract
-acting cAMP responsive elements within the promoters of target genes, it facilitates signal-dependent gene expression. From the discovery of CREB, which is ubiquitously expressed, it has been proven to be involved in a variety of cellular processes that include cell proliferation, adaptation, survival, differentiation, and physiology, through the control of target gene expression. In this review, we highlight the essential roles of CREB proteins in the nervous system, the immune system, cancer development, hepatic physiology, and cardiovascular function and further discuss a wide range of CREB-associated diseases and molecular mechanisms underlying the pathogenesis of these diseases.
Topics & Concepts
CREBBiologyTranscription factorGeneRegulation of gene expressionCell biologyPromoterCREB1Signal transductionGene expressionTranscription (linguistics)GeneticsPhilosophyLinguisticsProtein Kinase Regulation and GTPase SignalingNuclear Receptors and SignalingCytokine Signaling Pathways and Interactions