Epidemiology of Moyamoya disease in China: A nationwide hospital-based study
Zhang Dong, Liangran Huang, Zheng Huang, Qi Zhou, Xin Yang, Hongqiu Gu, Zixiao Li, Ying Shi, Lanxia Gan, Haibo Wang, Xvdong Ma, Yongjun Wang, Jizong Zhao
Abstract
BACKGROUND: The national epidemiologic data in mainland China is still absent for moyamoya disease (MMD). METHODS: This study was a nationwide hospital-based observational retrospective study to estimate epidemiological characteristics of MMD. The data was based on the Hospital Quality Monitoring System (HQMS), a national database which covers all tertiary hospitals in mainland China. This system consistently collects medical records including demographic characteristics, diagnoses, procedures, and expenses etc. for all inpatients. MMD was identified by ICD-10 code (I67·5) in HQMS. FINDINGS: = 2·375) by global spatial correlation analysis. INTERPRETATION: Our study reported the annual incidence of MMD was 1·14 per 100,000 inhabitants in mainland China during 2016 to 2018, and it was increasing year by year. The geographical distribution of MMD incidence presented as a clustered regional pattern, which may provide new view for future study on the etiology for MMD. FUNDING: National Natural Science Foundation of China and "13th Five-Year Plan" National Science and Technology Supporting Plan.