Elderly with COPD: comoborbitidies and systemic consequences
Mariano Mollica, Luigi Aronne, Giorgio Paoli, Martina Flora, Grazia Mazzeo, Stefania Tartaglione, Rita Polito, Tranfa Cm, M Ceparano, Klara Komici, Gennaro Mazzarella, Carlo Iadevaia
Abstract
Chronic obstructive pulmonary disease (COPD) represents a comple respiratory disorder characterized by persistent respiratory symptoms due to chronic airflow limitation caused by exposure to noxious particles/gases with an increased inflammatory response of the airways. COPD is common in older people, with an estimated prevalence of 10% in the US population aged > 75 years and is often accompanied by other concomitant chronic conditions that negatively impact prognosis and health status. The aim of this paper is to highlight the relationship between COPD and other comorbidities in elderly population. We focus our attention on the relationship existing between COPD and cardiovascular diseases, lung cancer, obstructive sleep apnoea syndrome, malnutrition/sarcopenia and osteoporosis with particular attention to adipokines, considering that adipose tissue plays a relevant role in the cross-talk between organs.