Effects of particle size reduction combined with β-cyclodextrin on the <i>in vitro</i> dissolution and <i>in vivo</i> relative bioavailability of ginsenosides in <i>Panax ginseng</i>
Chang Liu, Tao Yang, Zikuan Zhao, Tristan C. Liu, Kexin Li, Jianguo Liu, Peng Zhou
Abstract
experiments; in contrast, the deglycosylation states of PPT-type ginsenosides varied, which might be attributed to the relatively low abundance, glycosylation linkage, and potential involvement of the gut microbiota metabolism. Conclusively, ultrafine milling combined with a dispersant provides a simple and scalable manufacturing process that can effectively improve the bioavailability of ginseng products.
Topics & Concepts
GinsengBioavailabilityIn vivoChemistryDissolutionParticle sizeIn vitroPharmacologyTraditional medicineBiochemistryMedicineBiologyBiotechnologyOrganic chemistryPathologyAlternative medicinePhysical chemistryGinseng Biological Effects and ApplicationsPharmacological Effects of Natural CompoundsPhytoestrogen effects and research