Enamine <i>N</i>-Oxides: Synthesis and Application to Hypoxia-Responsive Prodrugs and Imaging Agents
Dahye Kang, Sheldon T. Cheung, Andrew Wong-Rolle, Justin Kim
Abstract
-oxide motif present an attractive opportunity for theranostic development that can address the need not only for new therapeutics but paired methods for patient stratification.
Topics & Concepts
ProdrugEnamineChemistryHypoxia (environmental)Tumor hypoxiaCombinatorial chemistryPharmacologyCancer researchBiochemistryBiologyOrganic chemistryMedicineCatalysisOxygenRadiation therapyInternal medicineCancer, Hypoxia, and MetabolismUbiquitin and proteasome pathwaysEpigenetics and DNA Methylation