Mild and Chemoselective Phosphorylation of Alcohols Using a Ψ-Reagent
Michał Ociepa, Kyle W. Knouse, David He, Julien C. Vantourout, Dillon T. Flood, Natalia M. Padial, Jason S. Chen, Brittany B. Sanchez, Emily Sturgell, Bin Zheng, Shenjie Qiu, Michael A. Schmidt, Martin D. Eastgate, Phil S. Baran
Abstract
An operationally simple, scalable, and chemoselective method for the direct phosphorylation of alcohols using a P(V)-approach based on the Ψ-reagent platform is disclosed. The method features a broad substrate scope of utility in both simple and complex settings and provides access to valuable phosphorylated alcohols that would be otherwise difficult to obtain.
Topics & Concepts
ReagentChemistryScope (computer science)PhosphorylationScalabilityCombinatorial chemistrySimple (philosophy)ChemoselectivitySubstrate (aquarium)Organic chemistryComputer scienceCatalysisBiochemistryDatabaseProgramming languageOceanographyPhilosophyGeologyEpistemologyChemical Synthesis and AnalysisCarbohydrate Chemistry and SynthesisOrganophosphorus compounds synthesis