Deubiquitinase USP18 promotes the progression of pancreatic cancer via enhancing the Notch1-c-Myc axis
Long Feng, Kai Wang, Ping Tang, Suyun Chen, Tiande Liu, Jun Lei, Rongfa Yuan, Zhigang Hu, Wen Li, Xin Yu
Abstract
. Moreover, we found that USP18 promoted pancreatic cancer progression via upregulation of Notch-1-dependent c-Myc. Mechanistically, USP18 interacts with and removes K48-linked ubiquitin chains from Notch1, thereby stabilizing Notch1 and promoting the Notch1-c-Myc pathway. Our work identifies and validates USP18 as a pancreatic cancer oncogene and provides a potential druggable target for this intractable disease.
Topics & Concepts
Deubiquitinating enzymePancreatic cancerCancer researchUbiquitinDownregulation and upregulationOncogeneCancerBiologyCancer cellGeneCell cycleGeneticsUbiquitin and proteasome pathwaysCancer-related Molecular PathwaysGenetics and Neurodevelopmental Disorders