Super-resolution microscopy: Insights into mitochondria–lysosome crosstalk in health and disease
Eric D. Leisten, A Woods, Yvette C. Wong
Abstract
Live super-resolution microscopy has allowed for new insights into recently identified mitochondria-lysosome contact sites, which mediate crosstalk between mitochondria and lysosomes, including co-regulation of Rab7 GTP hydrolysis and Drp1 GTP hydrolysis. Here, we highlight recent findings and future perspectives on this dynamic pathway and its roles in health and disease.
Topics & Concepts
LysosomeCrosstalkCell biologyMitochondrionGTP'AutophagyGTPaseMicroscopyChemistryBiologyBiochemistryMedicineEngineeringPathologyEnzymeApoptosisElectronic engineeringMitochondrial Function and PathologyAutophagy in Disease and TherapyCellular transport and secretion