<i>In situ</i> fluorescence imaging reveals that mitochondrial H<sub>2</sub>O<sub>2</sub> mediates lysosomal dysfunction in depression
Xin Wang, Qi Ding, Ying Tian, Wei Wu, Feida Che, Ping Li, Wen Zhang, Wei Zhang, Bo Tang
Abstract
We used two novel fluorescent probes for identifying a time-dependent pathological cascade beginning with mitochondrial H 2 O 2 accumulation under oxidant stress, which led to elevated lysosomal H 2 O 2 , and finally resulting in reduced GCase enzymatic activity in the brains of depressed mice.
Topics & Concepts
FluorescenceMitochondrionIn situPathogenesisDepression (economics)Cell biologyFluorescence-lifetime imaging microscopyChemistryBiophysicsBiologyMedicinePathologyPhysicsOpticsOrganic chemistryMacroeconomicsEconomicsTryptophan and brain disordersMitochondrial Function and PathologyNeuroscience and Neuropharmacology Research