Will Organoids Fill the Gap towards Functional Precision Medicine?
Federica Papaccio, Manuel Cabeza-Segura, Blanca García-Micó, Noelia Tarazona, Desamparados Roda, Josefa Castillo, Andrés Cervantes
Abstract
Precision medicine approaches for solid tumors are mainly based on genomics. Its employment in clinical trials has led to somewhat underwhelming results, except for single responses. Moreover, several factors can influence the response, such as gene and protein expression, the coexistence of different genomic alterations or post-transcriptional/translational modifications, the impact of tumor microenvironment, etc., therefore making it insufficient to employ a genomics-only approach to predict response. Recently, the implementation of patient-derived organoids has shed light on the possibility to use them to predict patient response to drug treatment. This could offer for the first time the possibility to move precision medicine to a functional environment.