Systemic administration of novel engineered AAV capsids facilitates enhanced transgene expression in the macaque CNS
Alexandra C. Stanton, Kim A. Lagerborg, Liana Tellez, Allison Krunnfusz, Emily M. King, Simon Ye, Isaac H. Solomon, Mohammadsharif Tabebordbar, Pardis C. Sabeti
Topics & Concepts
MacaqueTransgeneCapsidSystemic administrationBiologyGenetic enhancementCentral nervous systemRhesus macaqueGene deliveryTropismAdeno-associated virusVirologyTissue tropismGenetically modified mouseNeuroscienceVirusComputational biologyVector (molecular biology)GeneIn vivoGeneticsRecombinant DNAVirus-based gene therapy researchRNA Interference and Gene DeliveryHerpesvirus Infections and Treatments