Cooperativity mediated by rationally selected combinations of human monoclonal antibodies targeting the henipavirus receptor binding protein
Michael P. Doyle, Nurgun Kose, Viktoriya Borisevich, Elad Binshtein, Moushimi Amaya, Marcus Nagel, Edward J. Annand, Erica Armstrong, Robin Bombardi, Jinhui Dong, Kevin L. Schey, Christopher C. Broder, Larry Zeitlin, Erin A. Kuang, Zachary A. Bornholdt, Brandyn R. West, Thomas W. Geisbert, Robert W. Cross, James E. Crowe
Abstract
) infection, antibodies from both classes reduce morbidity and mortality and achieve synergistic protection in combination. These candidate mAbs might be suitable for use in a cocktail therapeutic approach to achieve synergistic potency and reduce the risk of virus escape.
Topics & Concepts
Hendra VirusVirologyMonoclonal antibodyAntibodyBiologyViral entryVirusReceptorAntigenImmunologyEbola virusViral replicationBiochemistryVirology and Viral Diseasesvaccines and immunoinformatics approachesVector-Borne Animal Diseases