Synthesis and Characterization of Thiophosphoramidate Morpholino Oligonucleotides and Chimeras
Heera K. Langner, Katarzyna Jastrzębska, Marvin H. Caruthers
Abstract
bioassay screens designed to evaluate their potential as microRNA inhibitors of hsa-miR-15b-5p in HeLa cells.
Topics & Concepts
MorpholinoOligonucleotideChemistryRNANucleaseDNAExonuclease IIICombinatorial chemistryDuplex (building)RNase HBiochemistryComputational biologyRNase PGeneBiologyGene knockdownEscherichia coliDNA and Nucleic Acid ChemistryRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniques