Biosafety evaluation of <i>Nannochloropsis oculata</i> and <i>Schizochytrium</i> sp. oils as novel human milk fat substitutes
Changyang Qiu, Yongjin He, Zicheng Huang, Weisang Qiu, Jian Huang, Mingzi Wang, Bilian Chen
Abstract
). For the 28-day sub-chronic study, five rat dietary feeds with 7.5% fat were designed to have the DHA content in the range from 0 to 2.0% using corn oil as a basal oil. After the 28-day treatment, SD rats fed HMFs did not show toxicity signs and adverse effects, based on the results of clinical observation, body weight, food consumption, behavior, hematology, clinical chemistry, and necropsy findings. These results could lead to the conclusion that the inclusion of the new synthesized HMFs into the pre-weaning SD rat diet was acceptable for SD rats and did not exhibit toxic characteristics and adverse features, indicating that the HMFs from microalgal oils were safe and had the potential to be used as a promising feedstock in infant formula.