Litcius/Paper detail

Discovery of novel 2,3-dihydro-1H-inden-1-ones as dual PDE4/AChE inhibitors with more potency against neuroinflammation for the treatment of Alzheimer's disease

Jie Liu, Lu Liu, Lei Zheng, Kai-Wen Feng, Haitao Wang, Jiangping Xu, Zhong‐Zhen Zhou

2022European Journal of Medicinal Chemistry27 citationsDOIOpen Access PDF

Topics & Concepts

DonepezilChemistryAchéNeuroinflammationNeuroprotectionPharmacologyAcetylcholinesteraseIC50PotencyHippocampusStereochemistryBiochemistryDementiaEnzymePsychologyNeuroscienceInternal medicineIn vitroDiseaseMedicinePhosphodiesterase function and regulationCholinesterase and Neurodegenerative DiseasesChemical synthesis and alkaloids