Discovery of novel 2,3-dihydro-1H-inden-1-ones as dual PDE4/AChE inhibitors with more potency against neuroinflammation for the treatment of Alzheimer's disease
Jie Liu, Lu Liu, Lei Zheng, Kai-Wen Feng, Haitao Wang, Jiangping Xu, Zhong‐Zhen Zhou
Topics & Concepts
DonepezilChemistryAchéNeuroinflammationNeuroprotectionPharmacologyAcetylcholinesteraseIC50PotencyHippocampusStereochemistryBiochemistryDementiaEnzymePsychologyNeuroscienceInternal medicineIn vitroDiseaseMedicinePhosphodiesterase function and regulationCholinesterase and Neurodegenerative DiseasesChemical synthesis and alkaloids