Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo
Amanda R. Wasylishen, Chang Sun, Sydney M. Moyer, Yuan Qi, Gilda P. Chau, Neeraj K. Aryal, Florencia McAllister, Michael P. Kim, Michelle Barton, Jeannelyn S. Estrella, Xiaoping Su, Guillermina Lozano
Abstract
mutations. Our results reveal a physiologic function of DAXX, provide a mechanism associated with impaired tissue regeneration and tumorigenesis, and expand our understanding of ERV regulation in somatic cells.
Topics & Concepts
Death-associated protein 6EndogenyGene silencingEndogenous retrovirusIn vivoBiologyCell biologyNeuroscienceGeneticsTranscription factorNuclear proteinGeneGenomeEndocrinologyEpigenetics and DNA MethylationGenomics and Chromatin DynamicsGenetics and Neurodevelopmental Disorders