Harnessing Rhodium-Catalyzed C–H Activation: Regioselective Cascade Annulation for Fused Polyheterocycles
Maneesh Kumar Reddy Singam, Undamatla Suri Babu, Attunuri Nagireddy, Jagadeesh Babu Nanubolu, Maddi Sridhar Reddy
Abstract
In the realm of transition-metal catalyzed arene functionalization, rhodium(III) catalysis is considered as exemplary due to its propensity to activate C-H bonds to obtain comprehensive molecular assembly. Herein, we demonstrate a new rhodium(III) catalyzed assembly of polyheterocyclic scaffolds via C-H activation and regioselective annulation of 4-arylbut-3-yn-1-amines with 4-hydroxy-2-alkynoates. Heterocyclization and trans-metalation prior to annulation is the key for initiation of this relay redox-neutral catalytic cascade.
Topics & Concepts
AnnulationRegioselectivityRhodiumChemistryCatalysisMetalationCombinatorial chemistryCascadeStereochemistryOrganic chemistryChromatographyCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsCatalytic Cross-Coupling Reactions