Biosensors Based on Acetylcholinesterase for the Detection of Pesticides organophosphates: Trends and Perspectives
Andressa Rose Castro Costa, Eliane Braga Ribeiro, Danilo Braga Ribeiro, Rodrigo Vieira Blasques, Paulo Roberto B. O. Maques, Marcelo dos Santos Targa, Gilvanda Silva Nunes
Abstract
Organophosphate (OPs)insecticides are capable of combating pests in food cultivation, acting through inhibition of the acetylcholinesterase enzyme (AChE), which catalyzes the hydrolysis of acetylcholine (ACh), a neurotransmitter fundamental for the functioning of the autonomic nervous system.The consumption of contaminated food and water can cause neurological diseases, therefore is a need for methods of rapid and reliable detection of these compounds, and here we highlight methods based on enzymatic biosensors.This work presents a wide discussion about the advances in the development of AChE-based biosensors for the detection of OPs, as well as suggestions for new investigations that may contribute to the area.