Structural insights into GIRK2 channel modulation by cholesterol and PIP2
Yamuna Kalyani Mathiharan, Ian W. Glaaser, Yulin Zhao, Michael J. Robertson, Georgios Skiniotis, Paul A. Slesinger
Abstract
interaction with the channel and promotes engagement of the cytoplasmic domain onto the transmembrane region. Mutagenesis of one of the CHS binding pockets eliminates cholesterol-dependent potentiation of GIRK2. Elucidating the structural mechanisms underlying cholesterol modulation of GIRK2 channels could facilitate the development of therapeutics for treating neurological diseases. VIDEO ABSTRACT.
Topics & Concepts
ChemistryModulation (music)CholesterolChannel (broadcasting)BiophysicsBiochemistryCell biologyComputer scienceBiologyPhysicsComputer networkAcousticsSignaling Pathways in Diseaseinterferon and immune responsesCalcium signaling and nucleotide metabolism