Obesity impacts hypoxia adaptation of the lung
Sophia Pankoke, Theresa Schweitzer, Rolf Bikker, Andreas Pich, Christiane Pfarrer, Christian Mühlfeld, Julia Schipke
Abstract
An "obesity paradox" is discussed for pulmonary diseases. By linking lung proteome analyses to pulmonary structure and function, we demonstrate that diet-induced obesity affects lung adaptation to chronic hypoxia in various ways. The observed changes include not only adverse but also protective effects and are associated with altered abundances of vascular and extracellular matrix proteins. These results highlight the existence of relevant differences in individuals with obesity that may influence the pathogenesis of lung diseases.
Topics & Concepts
Hypoxia (environmental)Internal medicinePulmonary hypertensionLungEndocrinologyObesityMedicineBiologyPhysiologyChemistryOxygenOrganic chemistryPulmonary Hypertension Research and TreatmentsChronic Obstructive Pulmonary Disease (COPD) ResearchHigh Altitude and Hypoxia