Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection With accumulation of mutations in a patient with poorly controlled Human Immunodeficiency Virus infection
Tongai Maponga, Montenique Jeffries, Houriiyah Tegally, Andrew D. Sutherland, Eduan Wilkinson, Richard Lessells, Nokukhanya Msomi, Gert U. van Zyl, Túlio de Oliveira, Wolfgang Preiser
Abstract
A 22-year-old woman with uncontrolled advanced human immunodeficiency virus (HIV) infection was persistently infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) beta variant for 9 months, the virus accumulating >20 additional mutations. Antiretroviral therapy suppressed HIV and cleared SARS-CoV-2 within 6 to 9 weeks. Increased vigilance is warranted to benefit affected individuals and prevent the emergence of novel SARS-CoV-2 variants.
Topics & Concepts
MedicineVirologyVirusCoronavirusHuman immunodeficiency virus (HIV)Respiratory systemImmunologyBetacoronavirusCoronavirus disease 2019 (COVID-19)PathologyInternal medicineDiseaseInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesViral gastroenteritis research and epidemiology