Neurological and Psychiatric Manifestations of Long COVID-19 and Their [18F]FDG PET Findings: A Review
Rizwanullah Hameed, Anuradha Rosario Bahadur, Shashi B. Singh, Juwairah Sher, Maia Todua, Leah Moradi, Sanjiv Bastakoti, Maeen Arslan, Hanfa Ajmal, Gha Young Lee, Cyrus Ayubcha, Thomas Werner, Abass Alavi, Mona‐Elisabeth Revheim
Abstract
For more than two years, lingering sequalae of COVID-19 have been extensively investigated. Approximately 10% of individuals infected by COVID-19 have been found to experience long-term symptoms termed “long COVID-19”. The neurological and psychiatric manifestations of long COVID-19 are of particular concern. While pathogenesis remains unclear, emerging imaging studies have begun to better elucidate certain pathological manifestation. Of specific interest is imaging with [18F]FDG PET which directly reflects cellular glycolysis often linked to metabolic and inflammatory processes. Seeking to understand the molecular basis of neurological features of long COVID-19, this review encompasses the most recent [18F]FDG PET literature in this area.