Inhibition of extracellular signal-regulated kinase/calpain-2 pathway reduces neuroinflammation and necroptosis after cerebral ischemia-reperfusion injury in a rat model of cardiac arrest
Wenyan Wang, Lu Xie, Xinsen Zou, Nuo Li, Yegui Yang, Zhi-jiang Wu, Xinyue Tian, Gaoyang Zhao, Menghua Chen
Topics & Concepts
NecroptosisMAPK/ERK pathwayCalpainNeuroinflammationReperfusion injuryKinaseBiologyCell biologyPharmacologyIschemiaMedicineInternal medicineInflammationProgrammed cell deathImmunologyApoptosisBiochemistryEnzymeCalpain Protease Function and RegulationNeuroinflammation and Neurodegeneration MechanismsSignaling Pathways in Disease