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Gemcitabine-facilitated modulation of the tumor microenvironment and PD-1/PD-L1 blockade generate a synergistic antitumor effect in a murine hepatocellular carcinoma model

Hua Wang, Xue He, Dong Fang, Xian Wang, Jing Guan, Zhenwang Shi, Xi Chen

2021Clinics and Research in Hepatology and Gastroenterology15 citationsDOI

Topics & Concepts

GemcitabineMedicinePD-L1Cancer researchHepatocellular carcinomaFlow cytometryImmune systemCD8BlockadeTumor microenvironmentApoptosisCytokineTumor necrosis factor alphaInternal medicineImmunotherapyReceptorImmunologyCancerChemistryBiochemistryCancer Immunotherapy and BiomarkersHepatocellular Carcinoma Treatment and PrognosisImmune cells in cancer
Gemcitabine-facilitated modulation of the tumor microenvironment and PD-1/PD-L1 blockade generate a synergistic antitumor effect in a murine hepatocellular carcinoma model | Litcius