A Chemical Approach to Introduce 2,6-Diaminopurine and 2-Aminoadenine Conjugates into Oligonucleotides without Need for Protecting Groups
Mimouna Madaoui, Dhrubajyoti Datta, Kelly Wassarman, Ivan Zlatev, Martin Egli, Bruce S. Ross, Muthiah Manoharan
Abstract
feasible at the 2-position.
Topics & Concepts
ChemistryOligonucleotideNucleotideConjugateCombinatorial chemistryProtecting groupNucleophilic substitutionNucleic acidStereochemistryLeaving groupAdenosineNucleophileFluorineOrganic chemistryBiochemistryCatalysisMathematical analysisDNAGeneMathematicsAlkylDNA and Nucleic Acid ChemistryClick Chemistry and ApplicationsAdvanced biosensing and bioanalysis techniques