Magnetic-controlled dandelion-like nanocatalytic swarm for targeted biofilm elimination
Yanjie Huang, Dong Liu, Ruirui Guo, Bin Wang, Zhengzuo Liu, Yijia Guo, Jian Dong, Yuan Lu
Abstract
. The synergistic antibacterial mechanisms of the mechanical factor and the chemical factor are further discussed. Under time-varying magnetic swarm control, the antibacterial performance of FSDMSsF NPs against bacteria was significantly improved. On this basis, the elimination effect of FSDMSsF NPs on bacterial biofilms is further discussed. The results showed that FSDMSsF NPs could target and eliminate biofilms through complex channels under the control of magnetic fields. In addition, the system could remove biofilms in occlusions by changing the morphology and movement mode of an FSDMSsF NP swarm under magnetic field control. The current work proposes a facile and physical-chemical synergistic strategy for effective antibacterial therapy. FSDMSsF NPs could effectively kill planktonic bacteria and remove stubborn biofilms through magnetic field guidance, achieving thorough antibacterial efficacy, which has great potential in the treatment of drug-resistant bacterial infections.