Synthesis, characterization and biological studies of pyrazole-linked Schiff bases and their copper( <scp>ii</scp> ) complexes as potential therapeutics
Pratima Kumari, Aman Kumar, Ramesh Kataria, Navin Kumar Kaushik, Mukhtar Ahmed, Azaj Ansari, Ekta Ekta, Mettle Brahma, Mulaka Maruthi, Yangala Sudheer Babu, Bijender Singh, Vinod Kumar
Abstract
The novel pyrazole-linked Schiff base-derived Cu( ii ) complexes were prepared, characterized, and evaluated for their biological potential.
Topics & Concepts
ChemistrySelectivityCytotoxicityHaemolysisCombinatorial chemistryCopperLigand (biochemistry)StereochemistryDocking (animal)Electron paramagnetic resonanceBiological activityA549 cellSchiff baseIn vitroNuclear chemistryStructure–activity relationshipQuantitative structure–activity relationshipMolecular modelMoleculeLead compoundMetal complexes synthesis and propertiesSynthesis and biological activityFerrocene Chemistry and Applications