Tofacitinib Promotes Functional Recovery after Spinal Cord Injury by Regulating Microglial Polarization via JAK/STAT Signaling Pathway
Hongdao Ma, Chenfeng Wang, Lin Han, Fanqi Kong, Zhixiao Liu, Bangke Zhang, Wenxiang Chu, Haibin Wang, Liang Wang, Qisheng Li, Weilin Peng, Haisong Yang, Chaofeng Han, Xuhua Lu
Abstract
Our study showed that TOF could regulate microglial activation via JAK / STAT pathway and promote the recovery of motor function after SCI, which is of great significance for the immunotherapy of SCI.
Topics & Concepts
MicrogliaTofacitinibNeuroprotectionInflammationIn vivoSignal transductionSpinal cord injuryJAK-STAT signaling pathwaystatMedicinePharmacologyCell biologyImmunologyBiologyCancer researchSpinal cordNeuroscienceSTAT3Rheumatoid arthritisBiotechnologyTyrosine kinaseNeuroinflammation and Neurodegeneration MechanismsImmune cells in cancerNeurogenesis and neuroplasticity mechanisms