Improvement effect of a next-generation probiotic <i>L. plantarum</i>-pMG36e-GLP-1 on type 2 diabetes mellitus <i>via</i> the gut–pancreas–liver axis
Hong Hu, Jie Luo, Ying Liu, Hongyu Li, Rui Jin, Shengjie Li, Jing Wei, Hong Wei, Tingtao Chen
Abstract
A next-generation probiotic Lactobacillus plantarum -pMG36e-GLP-1 was constructed to express GLP-1 in vivo , which may affect the gut-pancreas-liver axis, thereby relieving the symptoms of HFD/STZ-induced T2DM mice and db / db mice.
Topics & Concepts
Lactobacillus plantarumProbioticStreptozotocinDiabetes mellitusIn vivoPancreasType 2 Diabetes MellitusInternal medicineIsletEndocrinologyGenetically modified mouseGut floraType 2 diabetesApoptosisPancreatic isletsInsulinMedicineBiologyTransgeneImmunologyBiochemistryBacteriaLactic acidBiotechnologyGeneticsGeneGastrointestinal motility and disordersGut microbiota and healthProbiotics and Fermented Foods