SOCS3 inhibiting JAK-STAT pathway enhances oncolytic adenovirus efficacy by potentiating viral replication and T-cell activation
Danmei Yan, Guannan Li, Yuan Yuan, Huayi Li, Heng Cao, Yilin Dai, Ying Li, Zeyu Zhang, Fei Li, Yong Fang, Qinglei Gao
Topics & Concepts
statOncolytic virusSOCS3JAK-STAT signaling pathwayOncolytic adenovirusCancer researchViral replicationBiologySignal transductionSTAT3VirusCell biologyImmunologyTumor cellsTyrosine kinaseVirus-based gene therapy researchViral Infectious Diseases and Gene Expression in InsectsCAR-T cell therapy research