Cardiovascular Risk in Men with Prostate Cancer: Insights from the RADICAL PC Study
Darryl P. Leong, Vincent Fradet, Bobby Shayegan, Emmanuelle Duceppe, Robert Siemens, Tamim Niazi, Laurence Klotz, Ian H. Brown, Joseph L. Chin, Luke T. Lavallée, Negareh Mousavi, Patrick Luke, Himu Lukka, Darin Gopaul, Philippe D. Violette, Rob Hamilton, Margot K. Davis, Sarah Karampatos, Rajibul Mian, Guila Delouya, Yves Fradet, Som D. Mukherjee, David Conen, Annabel Chen‐Tournoux, Christopher Johnson, Amal Bessissow, George K. Dresser, Adnan Kazi Hameed, Husam Abdel‐Qadir, Alp Şener, Raveen Pal, P.J. Devereaux, Jehonathan H. Pinthus
Abstract
PURPOSE: We describe the cardiovascular risk profile in a representative cohort of patients with prostate cancer treated with or without androgen deprivation therapy. MATERIALS AND METHODS: We prospectively characterized in detail 2,492 consecutive men (mean age 68 years) with prostate cancer (newly diagnosed or with a plan to prescribe androgen deprivation therapy for the first time) from 16 Canadian sites. Cardiovascular risk was estimated by calculating Framingham risk scores. RESULTS: or greater, 24% low levels of physical activity, mean handgrip strength was 37.3 kg and 69% had a Framingham risk score consistent with high cardiovascular risk. Participants in whom androgen deprivation therapy was planned had higher Framingham risk scores than those not intending to receive androgen deprivation therapy, and this risk was abolished after adjustment for confounders. CONCLUSIONS: Two-thirds of men with prostate cancer are at high cardiovascular risk. There is a positive association between a plan to use androgen deprivation therapy and baseline cardiovascular risk factors. However, this association is explained by confounding factors.