Doxorubicin drug delivery using an electrospun nanofiber membrane of chitosan–polycaprolactone with metal–organic framework: Box–Behnken optimization, anticancer treatment, and antimicrobial activity
Fahad T. Alotaibi, Malak A. Alamri, Lina M. Alneghery, Ali M. Alaseem, Mohamed G. El‐Desouky, A.A. El-Bindary
Abstract
. Further optimization through a Box-Behnken statistical design improved both drug loading and release efficiency. Overall, these findings high spot the potential of the DOX@La-MOF/CS-PCL nanofiber membrane as a versatile and effective platform for controlled drug delivery, cancer treatment, and various biomedical applications.
Topics & Concepts
DoxorubicinDrug deliveryNanofiberChemistryElectrospinningNanocarriersPolycaprolactoneMembraneNanotechnologyChitosanControlled releaseBiocompatibilityPLGAPermeationDrugAntimicrobialNanocapsulesDrug carrierBiocompatible materialIn vivoTargeted drug deliveryCombinatorial chemistryBiophysicsMetal-Organic Frameworks: Synthesis and ApplicationsNanoplatforms for cancer theranosticsNanoparticle-Based Drug Delivery