Evaluating the impact of systematic hydrophobic modification of model drugs on the control, stability and loading of lipid-based nanoparticles
Cameron Hogarth, Keith Arnold, Andrew R. McLauchlin, Steve P. Rannard, Marco Siccardi, Tom O. McDonald
Abstract
An investigation of how the LogP value of an active controls the formation of lipid-based nanoparticles. Hydrophobically-modified drug analogues were formulated to give nanoparticles with much higher drug loadings than conventional lipid nanocarriers.
Topics & Concepts
Materials scienceNanoparticleStability (learning theory)Surface modificationNanotechnologyComputer scienceChemical engineeringEngineeringMachine learningProteins in Food SystemsAdvancements in Transdermal Drug DeliverySurfactants and Colloidal Systems