Incidental nanoparticles in black tea alleviate DSS-induced ulcerative colitis in BALB/c mice
Huan Han, Lijing Ke, Wei Xu, Huiqin Wang, Jianwu Zhou, Pingfan Rao
Abstract
, E-cadherin, ZO-1, and claudin-1) and increase of p-STAT3. The mixture of four tea components, which is the analogue of bioactive payloads carried by the NPs, was much less effective than the tea infusion and NPs. It shows that the NPs elevate the efficiency of polyphenols and caffeine in black tea in restoring the intercellular connection in the intestine, inhibiting mucosal inflammation, and alleviating ulcerative colitis. This work may inspire the development of tea-based therapeutics for treating inflammatory bowel diseases and have wide influences on value-added processing, quality evaluation, functionalization, and innovation of tea and other plant-based beverages.
Topics & Concepts
Ulcerative colitisCaffeineColitisPharmacologyBlack teaPolyphenolGallic acidChemistryMedicineBiochemistryImmunologyFood scienceInternal medicineAntioxidantDiseaseTea Polyphenols and EffectsInflammatory Bowel DiseaseTryptophan and brain disorders