Essential roles of the hypothalamic A11 region and the medullary raphe nuclei in regulation of colorectal motility in rats
Tomoya Sawamura, Natsufu Yuki, Kazuhiro Horii, Kiyotada Naitou, Hiroshi Yamaguchi, Akihiro Yamanaka, Takahiko Shiina, Yasutake Shimizu
Abstract
The A11 region and the raphe nuclei, constituting descending pain inhibitory pathways, are related to both intracolonic noxious stimuli-induced colorectal motility and stress-induced defecation. Our findings may provide an explanation for the concurrent appearance of abdominal pain and defecation disorders in patients with irritable bowel syndrome. Furthermore, overlap of the pathway controlling colorectal motility with the pathway mediating stress responses may explain why stress exacerbates bowel symptoms.
Topics & Concepts
Medullary cavityMotilityRapheInternal medicineRaphe nucleiEndocrinologyBiologyNeuroscienceMedicineCell biologySerotonergicSerotoninReceptorGastrointestinal motility and disordersDietary Effects on HealthDiet and metabolism studies