A concise and unexpected one-pot methodology for the synthesis of pyrazinone-fused pyridones
Jie Lei, Jia Xu, Dianyong Tang, Jingwei Shao, Hongyu Li, Zhong‐Zhu Chen, Zhigang Xu
Abstract
A post-Ugi/Michael/Retro-Michael reaction, aromatization and 5-<italic>exo-dig</italic> cyclization cascade reaction was developed and utilized for the synthesis of pyrazinone-fused pyridone derivatives under mild reaction conditions in one-pot.
Topics & Concepts
ChemistryAromatizationMichael reactionCombinatorial chemistryCascade reactionOne-pot synthesisCascadeOrganic chemistryCatalysisChromatographyMulticomponent Synthesis of HeterocyclesSynthesis and Reactions of Organic CompoundsSynthesis and Biological Evaluation