GPX4 Promoter Hypermethylation Induced by Ischemia/Reperfusion Injury Regulates Hepatocytic Ferroptosis
Chen Bai, Peilun Xiao, Yuting Chen, Fangfang Chu, Yue Jiao, Jiaqi Fan, Yuexia Zhang, Jiao Liu, Jiying Jiang, Shuna Yu
Abstract
Background and Aims: Glutathione peroxidase 4 (GPX4) is a key factor in ferroptosis, which is involved in ischemia-reperfusion injury. However, little is known about its role in hepatic ischemia-reperfusion injury (HIRI). This study aimed to investigate the role of GPX4 methylation in ferroptosis during HIRI. Methods: promoter methylation, and global methylation levels were then assessed. Results: promoter methylation. Conclusions: promoter and elevated levels of global hepatic methylation are involved in the regulation of ferroptosis.
Topics & Concepts
MedicineIschemiaReperfusion injuryGPX4Cancer researchCardiologyOxidative stressInternal medicineGlutathione peroxidaseSuperoxide dismutaseEpigenetics and DNA MethylationCancer-related gene regulationCancer-related molecular mechanisms research