High phosphate induces skeletal muscle atrophy and suppresses myogenic differentiation by increasing oxidative stress and activating Nrf2 signaling
Lin-Huei Chung, Shuting Liu, Shih‐Ming Huang, Donald M. Salter, Herng‐Sheng Lee, Yu‐Juei Hsu
Abstract
through oxidative stress-mediated protein degradation and both canonical (ROS-mediated) and non-canonical (p62-mediated) activation of Nrf2 signaling.
Topics & Concepts
MyogeninOxidative stressEndocrinologyInternal medicineMuscle atrophySkeletal muscleSarcopeniaMitochondrial ROSPhosphorylationC2C12Reactive oxygen speciesBiologyChemistryMitochondrionCell biologyMyogenesisMedicineNutrition and Health in AgingParathyroid Disorders and TreatmentsMuscle Physiology and Disorders