An inverse-breathing encapsulation system for cell delivery
Long‐Hai Wang, Alexander U. Ernst, James A. Flanders, Wanjun Liu, Xi Wang, Ashim K. Datta, Boris Epel, Mrignayani Kotecha, Klearchos K. Papas, Minglin Ma
Abstract
release, which improved cell survival in hypoxic conditions. Simulation-guided optimization yielded a device that restored normoglycemia of immunocompetent diabetic mice for over 3 months. Furthermore, functional islets were observed in scaled-up device implants in minipigs retrieved after 2 months. This inverse breathing device provides a potential system to support long-term cell function in the clinically attractive subcutaneous site.
Topics & Concepts
Encapsulation (networking)Delivery systemOxygenOxygenationBiomedical engineeringChemistryNanotechnologyMaterials scienceComputer scienceAnesthesiaMedicineComputer networkOrganic chemistryPancreatic function and diabetesTissue Engineering and Regenerative Medicine3D Printing in Biomedical Research