Novel 1,2,3-Triazole Erlotinib Derivatives as Potent IDO1 Inhibitors: Design, Drug-Target Interactions Prediction, Synthesis, Biological Evaluation, Molecular Docking and ADME Properties Studies
Guiqing Xu, Xiaoqing Gong, Yingying Zhu, Xiaojun Yao, Lizeng Peng, Ge Sun, Jianxue Yang, Longfei Mao
Abstract
was a novel and interesting IDO1 inhibitor for further development.
Topics & Concepts
ADMEErlotinibDocking (animal)TriazoleChemistryPharmacologyComputational biologyEGFR inhibitorsDrugCombinatorial chemistryStereochemistryBiochemistryMedicineBiologyEpidermal growth factor receptorOrganic chemistryReceptorNursingClick Chemistry and ApplicationsAdenosine and Purinergic SignalingTryptophan and brain disorders