mRNA therapeutics for disease therapy: principles, delivery, and clinical translation
Dawei Zhou, Ke Wang, Ying‐Ao Zhang, Ke Ma, Xiaochun Yang, Zhen‐Yi Li, Shoushan Yu, Kezheng Chen, Sheng‐Lin Qiao
Abstract
delivery, and low translational efficiency. Recent advances in molecular design and nanotechnology have helped overcome these challenges, and several mRNA formulations have demonstrated promising results in both animal and human testing against infectious diseases and cancer. This review provides an overview of the latest research progress in structural optimization strategies and delivery systems, and discusses key considerations for their future clinical use.
Topics & Concepts
BiopharmaceuticalComputational biologyTranslational medicineNanotechnologyMedicineRisk analysis (engineering)BiologyBiotechnologyMaterials sciencePathologyRNA Interference and Gene DeliveryRNA and protein synthesis mechanismsAdvanced biosensing and bioanalysis techniques