Inhibition of Sp1-mediated survivin and MCL1 expression cooperates with SLC35F2 and myeloperoxidase to modulate YM155 cytotoxicity to human leukemia cells
Jing‐Ting Chiou, Yuan‐Chin Lee, Chia‐Hui Huang, Liangjun Wang, Yijun Shi, Long‐Sen Chang
Topics & Concepts
SurvivinMCL1U937 cellCytotoxicityCancer researchCytotoxic T cellChemistryMyeloid leukemiaApoptosisp38 mitogen-activated protein kinasesAutophagyMolecular biologyDownregulation and upregulationPhosphorylationCell biologyBiologyMAPK/ERK pathwayBiochemistryIn vitroGeneCell death mechanisms and regulationAcute Myeloid Leukemia ResearchAutophagy in Disease and Therapy