Nanozyme and Stimulated Fluorescent Cu-Based Metal–Organic Frameworks (Cu-MOFs) Functionalized with Engineered Aptamers as a Molecular Recognition Element for Thrombin Detection in the Plasma of COVID-19 Patients
Gona K. Ali, Khalid M. Omer
Abstract
= 3). The label-free aptasensing probe was used successfully for the detection of thrombin in COVID-19 patients with satisfactory recoveries, 95-98%. Since the detection time of our aptasensor is relatively rapid (45 min) and due to the low-cost precursors and easy-to-operate characteristics, we believe that it has great potential to be used in point-of-care testing (POCT).
Topics & Concepts
AptamerFluorescenceDetection limitBiosensorChromogenicThrombinChemistrySurface modificationNanotechnologyCombinatorial chemistryMaterials scienceChromatographyMolecular biologyPhysical chemistryImmunologyPlateletQuantum mechanicsBiologyPhysicsAdvanced Nanomaterials in CatalysisAdvanced biosensing and bioanalysis techniquesBiosensors and Analytical Detection